師資

徐明華
教授
國家傑青
中科院百人計劃
0755-88018383
xumh@sustech.edu.cn
個人主頁

徐明華,浙江岱山人。1999年7月毕业于中国科学院上海有机化学研究所(导师:林国强研究员),获得理学博士学位;同年8月赴美国,先后在美国弗吉尼亚大学(University of Virginia)化學系和乔治城大学医学研究中心(Georgetown University Medical Center)从事博士后工作研究。2003年8月加入中国科学院上海有机化学研究所,2005年入选中国科学院“百人计划”,7月起任中国科学院上海药物研究所研究员、课题组长、博士生导师,新药研究国家重点实验室研究员。2018年受聘南方优乐园彩票开户大学教授。

主要從事有機不對稱合成及手性藥物方面的研究,致力于以一些重要有機分子及藥物分子合成爲導向的手性化學和手性技術探索。近年來在新型手性配體和催化劑的設計以及生物活性分子合成和新藥研究等方面取得了一些有較大影響和創新性的研究成果。在J. Am. Chem. Soc., Angew. Chem. Int. Ed., Acc. Chem. Res., Chem. Comm., Org. Lett.等国内外核心学术期刊上发表论文120余篇,多个工作受到国际国内同行的关注和好评,被美国化学会ACS “Heart Cut” (2),“Noteworthy Chemistry” (2),德國化學評論期刊Synfacts (32),英國Speciality Chemicals Magazine專欄,JACS Spotlights,Organic Chemistry Portal,X-MOL等選爲研究亮點報道;10篇論文被選爲期刊封面(其中1篇J. Am. Chem. Soc.封面);申請國內外專利24項,授權15項(美國專利2項)。應邀在國際性學術會議、海外知名大學作學術邀請報告100多次。

曾获中国化学会青年化学奖(2005),首屆藥明康德生命化學研究獎(2007),中国科学院朱李月华优秀教师奖(2012),中科院优秀研究生指导教师(2013),国家杰出青年科学基金(2013),上海市优秀学术带头人(2014),中国科学院特聘骨干研究员(2015),前沿有机化学亚洲核心计划讲座奖ACP Lectureship Award(日本3次、韩国、新加坡、泰国、台湾),以及法国斯特拉斯堡大学邀请教授、日本九州大学“Global 30”计划“Part-time Lecturer”、台湾国科会化学促进中心访问教授、日本北海道大学Hokkaido Summer Institute邀请教授等荣誉。2014年获上海市自然科学一等奖。2016年获国家自然科学二等奖(排名第二)。

 

榮譽及獎勵

2018? 深圳市国家级领军人才

2018? 日本北海道大学Hokkaido Summer Institute特别邀请教授

2018? 《科学通报》編委

2018? Elsevier开放期刊《Heliyon》編委

2016? 國家自然科學二等獎(第二完成人)

2016? PERCH-CIC Congress IX: 2016 International Congress for Innovation in Chemistry, June 26-29, Pattaya, Thailand (Plenary Lecture)

2016? 客座编辑Tetrahedron Symposia-in-Print for “Chiral Sulfur Ligands/Catalysts in Asymmetric Catalysis”

2015? 中國科學院特聘研究員(骨幹)

2015? 上海市研究生優秀學位論文指導教師

2014? 上海市自然科学一等奖(第二完成人)

2014? 亚洲核心计划讲座奖JSPS Asian Core Program Lectureship Award (Japan)

2014? 上海市优秀学术带头人

2014? 上海市研究生優秀學位論文指導教師

2013? 国家自然科学杰出青年基金

2013? 中国科学院优秀研究生指导教师

2013? 台湾国科会化学促进中心访问教授

2013? 日本九州大学(Kyushu University) 客座教授 (Part-Time Lecturer)

2012? BOSS XIII (the 13th Belgian Organic Synthesis Symposium), July 15-20, 2012, Leuven, Belgium (Plenary Lecture)

2012? 中国科学院朱李月华优秀教师奖

2011? 法国斯特拉斯堡大学(Univ. of Strasbourg)邀请教授(Invited Professor)

2010? 亚洲核心计划讲座奖Asia Core Program Lectureship Award (Korea)

2009? 亚洲核心计划讲座奖Asia Core Program Lectureship Awards (Taiwan and Thailand)

2008? 亚洲核心计划讲座奖Asian Core Program Lectureship Award (Singapore)

2008? 上海市青年优乐园彩票开户启明星后

2008? 中科院上海分院傑出青年优乐园彩票开户創新人才提名獎

2007? 亚洲核心计划讲座奖JSPS Asian Core Program Lectureship Award (Japan)

2007? 首屆藥明康德生命化學研究獎

2006? 亚洲核心计划讲座奖JAPS Asian Core Program Lectureship Award (Japan)

2005? 中国化学会青年化学奖

2005? 中国科学院“百人计划”

2005? 上海市青年优乐园彩票开户启明星

 

研究方向

1、不對稱合成與手性藥物研究

2、新型手性配體/催化劑的設計、合成以及在不對稱反應中的應用研究

3、具重要生理活性的有機分子或藥物分子的高效合成以及反應方法學研究

4、小分子藥物研究和發現

 

代表性論文

  • Yi Li, Bo Liu, and Ming-Hua Xu*, Rhodium-Catalyzed Enantioselective Alkenylation of Cyclic Ketimines: Practical Synthesis of Multifunctional Chiral α,α-Disubstituted Allylic Amine Derivatives”, Org. Lett. 2018, 20, 2306-2310. (Highlighted by Synfacts, 2018, 14(6), 0596)
  • ?Chun-Yan Wu, Yu-Fang Zhang, and Ming-Hua Xu*, “Ligand-Controlled Rhodium-Catalyzed Site-Selective Asymmetric Addition of Arylboronic Acids to α,b-Unsaturated Cyclic N-Sulfonyl Ketimines”, Org. Lett. 2018, 20, 1789-1793. (Highlighted by Synfacts, 2018, 14(6), 0597)
  • Zong-Fen Zhang, Dong-Xing Zhu, Wen-Wen Chen, Bin Xu* and Ming-Hua Xu*, “Enantioselective Synthesis of gem-Diaryl Benzofuran-3(2H)-ones via One-Pot Asymmetric Rhodium/Palladium Relay Catalysis”, Org. Lett. 2017, 19, 2726-2729. (Highlighted by Synfacts, 2017, 13(8), 0838, Abstracted by Organic Chemistry Portal)
  • Tao Jiang, Wen-Wen Chen, and Ming-Hua Xu*, “Highly Enantioselective Arylation of N,N-Dimethylsulfamoyl-Protected Aldimines Using Simple Sulfur–Olefin Ligands: Access to Solifenacin and (S)-(+)-Cryptostyline II”, Org. Lett. 2017, 19, 2138-2141. (Highlighted by Synfacts, 2017, 13(7), 0720)
  • Chun-Yan Wu, Yue-Na Yu, and Ming-Hua Xu*, “Construction of Chiral Tricyclic Indoles through a Rhodium-Catalyzed Asymmetric Arylation Protocol”, Org. Lett. 2017, 19, 384-387. (Highlighted by Synfacts, 2017, 13(3), 0298)
  • Wen-Wen Chen, and Ming-Hua Xu*, “Rhodium Complex Catalysis in Asymmetric Synthesis of Heterocycles”, Org. Biomol. Chem. 2017, 15, 1029-1050. (Invited Review; Cover Article)
  • Xu Zhang, Bin Xu,* and Ming-Hua Xu*, “Rhodium-Catalyzed Asymmetric Arylation of N- and O-Containing Cyclic Aldimines: Facile and Efficient Access to Highly Optically Active 3,4-Dihydrobenzo[1,4]oxazin-2-ones and Dihydroquinoxalinones”, Org. Chem. Front. 2016, 3, 944-948. (Highlighted by Organic Chemistry Portal; Abstracted by ChemInform, 2016, 10.1002/chin.201648022)
  • Yu-Fang Zhang, Diao Chen, Wen-Wen Chen, and Ming-Hua Xu*, “Construction of Cyclic Sulfamidates Bearing Two gem-Diaryl Stereocenters through a Rhodium-Catalyzed Stepwise Asymmetric Arylation Protocol”, Org. Lett. 2016, 18, 2726-2729. (Highlighted by Synfacts, 2016, 12(8), 0837; Abstracted by ChemInform, 2016, 10.1002/chin.201644021)
  • Diao Chen, Dong-Xing Zhu, and Ming-Hua Xu*, “Rhodium(I)-Catalyzed Highly Enantioselective Insertion of Carbenoid into Si-H: Efficient Access to Functional Chiral Silanes”, J. Am. Chem. Soc. 2016, 138, 1498-1501. (Highlighted by Synfacts, 2016, 12(4), 0385; also highlighted atJACS journal homepage; Abstracted by ChemInform, 2016, 10.1002/chin.201630222; Top 1% highly cited paper in the field of Chemistry as of March/April 2017, data from ESI)
  • Yi Li, Yue-Na Yu, and Ming-Hua Xu*, “Simple Open-Chain Phosphite-Olefin as Novel Ligand for Rh-Catalyzed Asymmetric Arylation of Cyclic Ketimines: Enantioselective Access to gem-Diaryl α-Amino Acid Derivatives”, ACS Catalysis, 2016, 6, 661-665. (Highlighted at ACS Catalysisjournal homepage)
  • Diao Chen, Xu Zhang, Wei-Yi Qi, Bin Xu and Ming-Hua Xu*, “Rhodium(I)-Catalyzed Asymmetric Carbene Insertion into B-H Bonds Using Unprecedented C1-Symmetric Chiral Diene Ligand: Highly Enantioselective Access to Functionalized Organoboranes”, J. Am. Chem. Soc. 2015,137, 5268-5271. (Cover Article, Featured in JACS Spotlights; Highlighted by Synfacts, 2015, 11(5), 0502; Abstracted by ChemInform, 2015, 10.1002/chin.201538189)
  • Tao Jiang, Zheng Wang and Ming-Hua Xu*, “Rhodium-Catalyzed Asymmetric Arylation of Cyclic N-Sulfonyl Aryl Alkyl Ketimines:Efficient Access to Highly Enantioenriched α-Tertiary Amines”, Org. Lett. 2015, 17, 528-531. (Highlighted by Synfacts, 2015, 11(4), 0367; Abstracted byChemInform, 2015, 10.1002/chin.201525171)
  • Yi Li, and Ming-Hua Xu*, “Rhodium-Catalyzed Asymmetric Tandem Cyclization for Efficient and Rapid Access to Underexplored Heterocyclic Tertiary Allylic Alcohols Containing a Tetrasubstituted Olefin”, Org. Lett. 2014, 16, 2712- 2715. (Highlighted by Synfacts, 2014, 10(7), 0680; Abstracted by ChemInform, 2014, 10.1002/chin.201443089)
  • Yi Li, and Ming-Hua Xu*, “Simple Sulfur-Olefins as New Promising Chiral Ligands for Asymmetric Catalysis”, Chem. Commun. 2014, 50, 3771- 3782. (Invited Feature Article; Cover Article; Abstracted by ChemInform, 2014, 45, 22-025)
  • Yi Li, Dong-Xing Zhu, and Ming-Hua Xu*, “A New Versatile Approach to Enantioenriched 3-Hydroxyoxindoles, 1,3-Dihydroisobenzofuran and 3-Isochromanone Derivatives by Rhodium-Catalyzed Asymmetric Arylation/Cyclization Sequence”, Chem. Commun. 2013, 49, 11659-11661. (Highlighted by Synfacts, 2014, 10(3), 0285; selected as an article of ChemComm Editor’s Choice; Abstracted by ChemInform, 2014, 45, 17-025)
  • Hui Wang, Tao Jiang, and Ming-Hua Xu*, “Simple Branched Sulfur-Olefins as Chiral Ligands for Rh-Catalyzed Asymmetric Arylation of Cyclic Ketimines: Highly Enantioselective Construction of Tetrasubstituted Carbon Stereocenters”, J. Am. Chem. Soc. 2013, 135, 971-974. (Highlighted by Synfacts, 2013, 9(4), 0416; Abstracted by ChemInform, 2013, 44, 26-123; Top 1% highly cited paper in the field of Chemistry as of March/April 2017, data from ESI)
  • Shen-Shuang Jin, Hui Wang, Ting-Shun Zhu, and Ming-Hua Xu*, “Design of N-Cinnamyl Sulfinamides as New Sulfur-Containing Olefin Ligands for Asymmetric Catalysis: Achieving Structural Simplicity with a Categorical Linear Framework”, Org. Biomol. Chem. 2012, 10, 1764-1768. (Cover Article, highlighted on the OBC blog and also by Synfacts, 2012, 8(6), 0651; Abstracted by ChemInform, 2012, 43, 29-095; Featured in the top 10% of the most highly cited OBC articles published in the latest Impact Factor window (2011-2012))
  • Ting-Shun Zhu, Shen-Shuang Jin, and Ming-Hua Xu*, “Rhodium-Catalyzed Highly Enantioselective 1,2-Addition of Arylboronic Acids to α-Ketoesters and α-Diketones Using Simple Chiral Sulfur-Olefin Ligands”, Angew. Chem. Int. Ed. 2012, 51, 780-783. (Highlighted by Synfacts,2012, 8(4), 0422; Abstracted by ChemInform, 2012, 43, 23-023).
  • Shen-Shuang Jin, Hui Wang, and Ming-Hua Xu*, “Design of N-Sulfinyl Homoallylic Amines as Novel Sulfinamide-Olefin Hybrid Ligands for Asymmetric Catalysis: Application in Rh-Catalyzed Enantioselective 1,4-Additions”, Chem. Commun. 2011, 47, 7230-7232. (Highlighted bySynfacts, 2011, 9, 0985; Abstracted by ChemInform, 2011, 42, 44-025)
  • Zhi-Qian Wang, Chen-Guo Feng, Shu-Sheng Zhang, Ming-Hua Xu* and Guo-Qiang Lin*, “Rhodium-Catalyzed Asymmetric Conjugate Addition of Organoboronic Acids to Nitroalkenes Using Chiral Bicyclo[3.3.0] Diene Ligands”, Angew. Chem. Int. Ed., 2010, 49, 5780-5783. (Highlighted by Synfacts, 2010, 11, 1275 and Organic Chemistry Portal, 2011, July, 18; Abstracted by ChemInform, 2010, 41, 50-068)
  • Guo-Qiang Lin,* Ming-Hua Xu, Yu-Wu Zhong and Xing-Wen Sun, “An Advance on Exploring N-tert-Butanesulfinyl -imines in Asymmetric Synthesis of Chiral Amines”, Acc. Chem. Res. 2008, 41, 831-840. (Abstracted by ChemInform, 2008, 39, 45-237; Top 1% highly cited paper in the field of Chemistry as of March/April 2017, data from ESI)
  • Zhi-Qian Wang, Chen-Guo Feng, Ming-Hua Xu*, and Guo-Qiang Lin*, “Design of C2-Symmetric Tetrahydropentalenes as New Chiral Diene Ligands for Highly Enantioselective Rh-Catalyzed Arylation of N-Tosylarylimines with Arylboronic Acids”, J. Am. Chem. Soc. 2007, 129, 5336-5337. (Highlighted by Synfacts, 2007, 08, 0847 and Organic Chemistry Portal; Abstracted by ChemInform, 2007, 38, 37-073; Top 1% highly cited paper in the field of Chemistry as of March/April 2017, data from ESI).
  • Xing-Wen Sun, Ming-Hua Xu* and Guo-Qiang Lin*, “Room-Temperature Highly Diastereoselective Zn-Mediated Allylation of Chiral N-tert-Butanesulfinyl Imines: Remarkable Reaction Condition Controlled Stereoselectivity Reversal”, Organic Letters 2006, 8, 4979-4982. (Highlighted by Chemistry.Org of the American Chemical Society as a “Heart Cut” (Dec 4, 2006); also highlighted by Synfacts, 2006, 12, 1266; Abstracted by ChemInform, 2007, 38, 10-029).
  • Yu-Wu Zhong, Yi-Zhou Dong, Kai Fang, Kenji Izumi, Ming-Hua Xu* and Guo-Qiang Lin*, “A Highly Efficient and Direct Approach for Synthesis of Enantiopure α-Amino Alcohols by Reductive Cross-Coupling of Chiral N-tert-Butanesulfinyl Imines with Aldehydes”, J. Am. Chem. Soc.2005, 127, 11956-11957. (Highlighted by Synfacts, 2005, 3, 0331 and Organic Chemistry Portal; Abstracted by ChemInform, 2005, 37, 01-088).
  • Yu-Wu Zhong, Ming-Hua Xu* and Guo-Qiang Lin, Samarium Diiodide-Induced Asymmetric Synthesis of Optically Pure Unsymmetrical Vicinal Diamines by Reductive Cross-Coupling of Nitrones with N-tert-Butanesulfinyl Imines. Organic Letters 2004, 6, 3953-3956. (Highlighted by Chemistry.Org of the American Chemical Society as a “Heart Cut” (Nov 15, 2004); also highlighted by Angew. Chem. Int. Ed. 2005, 44, 7833; Abstracted by ChemInform, 2005, 36, 06-080)
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